1-(4-chloro phenyl)-2-cyclopropyl-1-propanone

1-(4-chloro phenyl)-2-cyclopropyl-1-propanone

1-(4-Chlorophenyl)-2-cyclopropyl-1-propanone is an organic compound with the molecular formula C₁₂H₁₃ClO. It consists of a propanone (ketone) backbone substituted with a 4-chlorophenyl group at the 1-position and a cyclopropyl group at the 2-position. This structure combines aromatic, aliphatic, and cyclic features, making it a valuable intermediate in pharmaceutical and agrochemical synthesis.

Key Properties

Chemical Formula: C₁₂H₁₃ClO

Molecular Weight: 208.68 g/mol

Appearance: Colorless to pale yellow liquid or low-melting solid

Boiling Point: ~280–300°C (estimated)

Solubility:

Soluble in organic solvents (e.g., ethanol, acetone, DCM)

Insoluble in water

Applications

Pharmaceuticals:

Intermediate for CNS-active drugs (e.g., antidepressants, anticonvulsants) due to the cyclopropyl moiety’s metabolic stability.

Potential precursor for protease inhibitors or kinase modulators.

Agrochemicals:

Used in the synthesis of pesticides or herbicides leveraging the 4-chlorophenyl group’s bioactivity.

Organic Synthesis:

The ketone group allows further transformations (e.g., reduction to alcohols, Grignard reactions).

Cyclopropyl ring can participate in ring-opening reactions for complex molecule assembly.

Safety & Handling

Hazards: May irritate skin/eyes; avoid inhalation.

Stability: Stable under inert conditions but sensitive to strong acids/bases.

Storage: Keep in a cool, dry place, sealed under nitrogen.

PPE: Gloves, goggles, and fume hood recommended.